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General Information
Alias: CKS1B (1q gain), ASS1 (+9), CCND1/IGH (IGH/CCND1 fusion or +11), IGH rearrangement, PML (+15) and p53 (17p deletion), FGFR3/IGH, MAF/IGH
Performed: Sun-Sat
Turn Around Time: 5-14 days
CPT Codes: 88271 x6; 88275 x6; 88291
Performed By: Referral Lab
Notes: Fluorescence in situ hybridization (FISH) panel is performed on CD138+ sorted cells (assuming specimen is sufficient for sorting) for multiple myeloma prognosis-specific genomic abnormalities: CKS1B (1q gain), ASS1 (+9), CCND1/IGH (IGH/CCND1 fusion or +11), IGH rearrangement, PML (+15) and p53 (17p deletion). If IGH is positive and not partnered with CCND1, additional testing will include FGFR3/IGH and MAF/IGH.
Clinical Utility: Aid in risk stratification of individuals with multiple myeloma. Recommended at initial diagnosis and in low-risk individuals at time of relapse.
Link:
Multiple Myeloma Panel by FISH
Components
| Name |
Method |
Sex |
Age Range |
Ref. Range Low |
Ref. Range High |
Units |
| Multiple Myeloma Panel by FISH |
Fluorescence in situ Hybridization |
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Specimen Requirements
| Type |
Container |
Volume |
Units |
Collection / Delivery |
Storage / Transport |
Off Campus |
| Whole Blood |
4mL Grn Na Hep |
|
|
|
Room Temperature |
|
| Bone Marrow |
Heparinized Syringe |
|
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|
Room Temperature |
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